Urinary pyridinoline and deoxypyridinoline, pyridiniumcrosslinks released during breakdown of mature collagen, might serve asuseful markers of bone resorption. Before their role can be identified,reference values must be established. In this study, free pyridinoline(f-Pyr), free deoxypyridinoline (f-DPyr), and creatinine (Cr) weremeasured in first morning void urine samples from 250 girls and 265 boys between the ages of 4 and 10 years. Overall, there was a decreasein f-Pyr:Cr and f-DPyr:Cr ratios with increasing age in both sexes, butthere was a wide range of values for individuals of similar ages.Further studies are required to assess whether urinary pyridiniumcrosslink excretion is sufficiently deranged in conditions affectingbone metabolism for the measurement of these compounds to be ofclinical value.
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